Dr Stephen Holman
Postdoctoral fellow
Lab A, Centre for Proteome Research
Institute of Integrative Biology
University of Liverpool,
Crown Street
Liverpool L69 7ZB
Tel: +44 151 794 5344
Email: stephen.holman[at]liverpool.ac.uk
Postdoctoral fellow
Lab A, Centre for Proteome Research
Institute of Integrative Biology
University of Liverpool,
Crown Street
Liverpool L69 7ZB
Tel: +44 151 794 5344
Email: stephen.holman[at]liverpool.ac.uk
Stephen obtained a Ph.D. in Chemistry from the University of Southampton. Working in the group of Dr. John Langley and in collaboration with Pfizer Global Research and Development, he applied mass spectrometry to analyse small molecule drug metabolites to facilitate their rapid and definitive characterisation. Following this, Stephen moved to the Michael Barber Centre for Mass Spectrometry at the University of Manchester to undertake post-doctoral research in the laboratory of Professor Claire Eyers. Here, he was responsible for the analytical aspects of a large-scale quantification study aiming to determine absolute abundances of a large proportion of the Saccharomyces cerevisiae (baker’s yeast) proteome as a member of the Census of the Proteome of Yeast (CoPY project). This involved aspects of sample preparation, LC-MS method development (particularly design of SRM assays) and data processing and interpretation. Stephen continued this work upon the relocation of Professor Eyers’ group to the Institute of Integrative Biology in 2013.
In 2014, Stephen embarked on a further post-doctoral project, this time focussed on the effect of DNA damage on the PTM status of the NF-κB pathway in human cells. The work involves elucidating how PTMs, particularly phosphorylation, are regulated over time, and correlating these changes to NF-κB activity. This work is in collaboration with the group of Professor Neil Perkins (Newcastle University).
Stephen is a regular presenter at national and international meetings, is currently a committee member of the Northwest Analytical Division of the Royal Society of Chemistry, was previously the Special Interest Group co-ordinator for the British Mass Spectrometry Society, has acted as a tutor on educational courses for national societies, and is a regular referee for several journals in addition to being an associate editorial board member for Rapid Communications in Mass Spectrometry. Stephen is also a STEM ambassador.
In 2014, Stephen embarked on a further post-doctoral project, this time focussed on the effect of DNA damage on the PTM status of the NF-κB pathway in human cells. The work involves elucidating how PTMs, particularly phosphorylation, are regulated over time, and correlating these changes to NF-κB activity. This work is in collaboration with the group of Professor Neil Perkins (Newcastle University).
Stephen is a regular presenter at national and international meetings, is currently a committee member of the Northwest Analytical Division of the Royal Society of Chemistry, was previously the Special Interest Group co-ordinator for the British Mass Spectrometry Society, has acted as a tutor on educational courses for national societies, and is a regular referee for several journals in addition to being an associate editorial board member for Rapid Communications in Mass Spectrometry. Stephen is also a STEM ambassador.
B.Sc. Anglia Ruskin University
Ph.D. University of Southampton
Ph.D. University of Southampton